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Title Photonic crystal fibre based sensors for label-free detection of biomolecules
Author Duval, Aurelien (Fibers & Nonlinear Optics, COM•DTU Department of Communications, Optics & Materials, Technical University of Denmark, DTU, DK-2800 Kgs. Lyngby, Denmark)
Supervisor Jensen, Jesper Bo Damm (Fibers & Nonlinear Optics, COM•DTU Department of Communications, Optics & Materials, Technical University of Denmark, DTU, DK-2800 Kgs. Lyngby, Denmark)
Bjarklev, Anders Overgaard (management, COM•DTU Department of Communications, Optics & Materials, Technical University of Denmark, DTU, DK-2800 Kgs. Lyngby, Denmark)
Institution Technical University of Denmark, DTU, DK-2800 Kgs. Lyngby, Denmark
Thesis level Master's thesis
Year 2004
Abstract During the last few years, the introduction of highly sensitive biochemical sensors have fostered the development of molecular biology, and major discoveries are now possible in the field of genomics and medicine, leading to a more in-depth knowledge about the internal functions of our cells. The introduction of photonic crystal fibers is revolutionizing the field of sensors thanks to their versatility and the control they give in tuning the properties of light. This thesis presents an original implementation of a label-free sensor for biomolecules based on the properties of photonic crystal fibers. The biomolecules are detected inside the sir holes of a photonic crystal fiber, where a more tight coupling between light and molecular targets is expected. To enable the direct detection of molecules without the help of fluorphores, a long-period grating writing facility based on a CO2 laser is realized. The biomolecules-silica interactions are investigated by the means of evanescentwave fluorescence spectroscopy using a side illumination setup.
Pages 92
Admin Creation date: 2006-06-22    Update date: 2007-02-24    Source: dtu    ID: 184768    Original MXD