Beta 1


Title Changes in brain function in healthy individuals who are at risk for depression
Author Harder, Stine
Wiener, Rikke
Supervisor Hansen, Lars Kai (Intelligent Signal Processing, Department of Informatics and Mathematical Modeling, Technical University of Denmark, DTU, DK-2800 Kgs. Lyngby, Denmark)
Institution Technical University of Denmark, DTU, DK-2800 Kgs. Lyngby, Denmark
Thesis level Bachelor thesis
Year 2009
Abstract The main aim of this assignment is to investigate if any differences can be seen in the brain activity for people with high risk of developing depression. It is known that depression is tightly connected to alterations in the serotonergic system. These alterations can affect ones response to a given task. The study has been performed on a group of people who are particularly disposed to depression plus at a control group. Each group contains 11 matched individuals. The go/no-go task is used to investigate in which areas the disposed high risk group exhibit respectively reduced or increased activity. Areas involved in inhibition are emphasized. The data has been achieved with functional magnetic resonance imaging. The following processing of the data is made with the MATLAB program SPM, Statistical Parametric Mapping. The output is statistical probability images on which significant activity is shown. The results from the control group show activity in some areas concerning inhibitory control and in areas involved in the processing of sensory inputs. These results are consistent with prior investigations on the topic. Consequently the results are a solid foundation to further investigations concerning the high risk group. Results from the high risk group show that the same areas contain respectively reduced and increased activity in the inhibitory areas for the two contrasts AlternativeGo > Go and NoGo > Go. This gives a very contradictory foundation for making a valid conclusion. Our results can only show that the disposed high risk group does not exhibit any significant differences from the normal group. Tendencies are seen and a more valid result can be obtained by repeating the study with larger groups. This could determine if activated areas are in fact significant or if they have arisen due to coincidence, for example type 1 errors.
Imprint Technical University of Denmark (DTU) : Kgs. Lyngby, Denmark
Series IMM-B.Sc.-2009-02
Fulltext
Original PDF bac09_02.pdf (2.43 MB)
Admin Creation date: 2009-06-10    Update date: 2010-08-25    Source: dtu    ID: 244414    Original MXD