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Title Digital X-ray of metarcarpal and phalangeal bones for assessment of bone density
Author Iversen, Sanne Lundstrøm
Supervisor Jørgensen, Henrik L. (Department of Clinical Biochemistry, Bispebjerg Hospital. DK)
Lauritzen, Jes B. (Department of Orthopaedic Surgery, Bispebjerg Hospital. DK)
Wilhjelm, Jens E. (Biomedical Engineering, Department of Electrical Engineering, Technical University of Denmark, DTU, DK-2800 Kgs. Lyngby, Denmark)
Institution Technical University of Denmark, DTU, DK-2800 Kgs. Lyngby, Denmark
Thesis level Master's thesis
Year 2009
Abstract Osteoporosis is a metabolic bone disease characterized by reduced bone density, increased skeletal fragility, and fracture. Based on WHO´s definition of osteoporosis 500.000- 600.000 Danish people over the age of 50 have osteoporosis. Osteoporotic patients have an increased mortality rate due to complications of fractures or concomitant medical diseases. Therefore, is it important to find better diagnostic methods to identify persons at increased risk of developing osteoporosis. One potential candidate might be radiographic absorptiometry. Radiographic absorptiometry is a technique for bone mass measurement from radiography of peripheral sites, most commonly the hand or heel. Computerized image processing has been applied to radiography, with the result that current radiographic absorptiometic techniques have become more reliable and easier to use. The relatively low cost and lack of need for specialized equipment make radiographic absorptiometry a highly attractive option for the diagnosis of osteoporosis. The aim of this study was to evaluate the accuracy and precision of a radiographic absorptiometry method for assessment of BMD of the metacarpal bone and the proximal phalangeal bone and to compare the results from radiographic absorptiometry with those of DXA of the spine, femur and site specifically at the metacarpal and proximal phalangeal bones. The precision study showed a low coefficient of variation in the intra serial study. A higher coefficient of variation was found in the inter serial and inter machine study, warranting further studies to increase precision. The accuracy study showed that all the test subjects had a higher correlation coefficient between the metacarpal ROIs than between the proximal phalangeal ROIs in the site specific comparison with DXA. Based on the results it can be concluded that there is basis for further investigation of the use of radiographic absorptiometry to diagnose osteoporosis.
Imprint Technical University of Denmark (DTU) : Kgs. Lyngby, Denmark
Pages 130
Original PDF sanne_lundstroem_iversen.pdf (10.46 MB)
Admin Creation date: 2009-11-23    Update date: 2009-11-23    Source: dtu    ID: 252870    Original MXD