Beta 1


Title A simulator for digital microfluidic biochips
Author Lukas, Maciej
Supervisor Pop, Paul (Embedded Systems Engineering, Department of Informatics and Mathematical Modeling, Technical University of Denmark, DTU, DK-2800 Kgs. Lyngby, Denmark)
Institution Technical University of Denmark, DTU, DK-2800 Kgs. Lyngby, Denmark
Thesis level Master's thesis
Year 2010
Abstract A lab on chip is a concept that in recent years became a very popular alternative to traditional laboratories. A digital micro fluidic biochip is one of the devices that are strictly connected to the lab on chip concept. Digital micro fluidic biochips are very small devices capable of replacing conventional laboratories by performing all the necessary biochemical functions using droplets with volumes as low as picolitres. A digital biochip is composed of a two-dimensional array of identical cells, together with reservoirs for storing the substances. Each cell consists of several control electrodes, used for moving the droplets on the array. This is done by applying voltages to required electrodes. Any biochemical application can be decomposed into a series of basic micro fluidic operations (e.g., creating a droplet with a precise volume, mixing two droplets, diluting a droplet with a buer solution). Performing such operations requires transporting droplets on the array according to a certain pattern, therefore a sequence of electrodes activation is required. Given a biochemical application in the form of a set of micro fluidic operations, together with the activated electrodes at each moment, a simulator provides a graphical representation of the droplets movement on the array, either as a realistic model showing the exact droplet movement or as a simplified model, with modules representing the operations. The simulator also captures specific situations that may appear during the execution of the application, like an in-correct execution of operations. The simulator can provide useful information on the efficiency of the current design, before an actual chip goes into production. This thesis provides brief theoretical information about the micro fluidics field and the biochips. Furthermore, a simulator concept is provided, followed by the detailed information on its design and implementation, including two aforementioned models (simplified and realistic) and faults simulation. Finally, a technical documentation on the tool itself is provided, followed by a list of possible future extensions.
Imprint Technical University of Denmark (DTU) : Kgs. Lyngby, Denmark
Series IMM-M.Sc.-2010-72
Fulltext
Original PDF ep10_72_net.pdf (2.31 MB)
Admin Creation date: 2010-09-02    Update date: 2010-09-02    Source: dtu    ID: 266420    Original MXD